The subsequent adverse reactions have already been determined through submit-acceptance use of hyaluronidase products and solutions. Mainly because these reactions are documented voluntarily from a populace of unsure dimension, It's not at all usually probable to reliably estimate their frequency or create a causal romance to drug exposure. The most often claimed adverse reactions have already been regional injection internet site reactions.
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During subcutaneous fluid administration, Exclusive care needs to be taken in pediatric patients to stop over hydration by controlling the rate and total volume from the infusion [see DOSAGE AND ADMINISTRATION].
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Clinical hydration specifications for children can be obtained through administration of subcutaneous fluids facilitated with VITRASE.
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Instruct sufferers they may not acquire furosemide, the benzodiazepines, phenytoin, dopamine and/or alpha agonists with HYLENEX recombinant. These medicines are actually uncovered to get incompatible with hyaluronidase.
Understanding the underlying pathophysiology of such nodules is complicated as a result of restricted entry to investigations and also the reluctance of patients to permit tissue sampling.
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Inject a hundred and fifty U HYLENEX recombinant ahead of subcutaneous fluid administration. It can facilitate absorption check here of one,000 mL or more of Alternative. The dosage of subcutaneous fluids administered is dependent upon the age, pounds, and scientific affliction of the affected person and laboratory determinations.